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KMID : 0356419960140010035
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Journal of Korean Andrology
1996 Volume.14 No. 1 p.35 ~ p.42
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Intracavernous Self-Injection of Papaverine Plus Phenotolamine for Treatment of Impotence : Long-Term Follow-Up in 156 Patients Treated for More than 1 Year
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Abstract
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The intracavernous injection of a mixture of papaverine and phentolamine is more satisfactory than papaverin alone as a treatment for erectile dysfunction but is associated with a relatively high incidence of fibrous plaque formation and
priapism.
We
reviewed 156 impotent men, 28 to 77 years of age, who used intracavernous self-injection with papaverine (23.3mg/mL) plus phentolamine (0.9mg/mL) for more than 1 year (average 3.0±1.8 years). The mean dose of the vasoactive mixture per injection
was
0.43±0.23mL.
The patients with psychogenic or neurogenic impotence required significantly lower doses to obtain a functionally adequate erection than did those with either vasculogenic or diabetogenic impotence. One hundred forty-four patients (92.3%) were
able
to
get an erection sufficient for sexual activity. The drop-out rate was 25.0%, and the most common cause was inadequate erection. Nineteen patients (12.2%) showed spontaneous recovery of erection during the therapy . Thirty-three patient (21.2%)
developed
fibrous plaques at the injection site.
The incidence of this complication was not significantly correlated with the frequency of self-injection or the total number of injections but was significantly correlated with the dose of drug per injection (p <0.05). Fibrous plaque appears to
be
relatively common in patients using intracavernous self-injection with papaverine and phentolamine for more than 1 year. Thus, careful attention should be paid to the possible development of fibrous plaques after high-dose therapy.
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KEYWORD
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